PPAR Research · 2012 · 18 citations · 73 references
MedicineBiochemistryPharmacologyClinical PharmacologyInflammationPerioperative PharmacologyAnti-inflammatory PharmacologyHepatic NecrosisHepatic PathophysiologyLipoprotein MetabolismNeuroprotectionOxidative Stress In InflammationAntioxidant PropertiesHepatic Inflammatory InjuryInflammation In Liver InjuryLipoprotein Metabolism RegulationLiver SurgeryNf-κb SignalingOrgan Ischemia-reperfusion InjuryOxidative Stress In Ischemia-reperfusion Injury
Hepatic ischemia-reperfusion (IR) injury is a serious clinical problem. Minimizing the adverse effect of ischemia-reperfusion injury after liver surgery or trauma is an urgent need. It has been proved that besides the effect of regulating the lipid and lipoprotein metabolism, PPARα also undertakes the task of organ protection. In this paper, related literature has been summarized and we come to the conclusion that administration of PPARα agonists can strengthen the antioxidant and anti-inflammation defense system by the upregulation of the expression of antioxidant enzymes and inhibition of NF-κB activity. This may provide a potential clinical treatment for hepatic ischemia-reperfusion injury.
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De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling
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The PPARα–leukotriene B4 pathway to inflammation control
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