Synthesis and Biological Evaluation of an Indomethacin Library Reveals a New Class of Angiogenesis‐Related Kinase Inhibitors

Abstract

Capture and release: Indomethacin has served as a lead compound for the synthesis of a library that revealed a new class of kinase inhibitors. A synthetic approach termed “resin-capture-release” was developed (see scheme) that allowed a large library to be synthesized easily. Six of the library compounds were found to be inhibitors of angiogenesis-related receptor tyrosine kinases.