Radiofrequency Encoded Combinatorial Chemistry

Abstract

The combinatorial synthesis of peptides on a support can be traced exactly by the incorporation of semi-conductor memory chips in Microreactors containing polymer beads (see picture on the right). Before each coupling step the chip is encoded with a radiofrequency signal (for example A); the sequence of signals encoding the complete amino acid sequence (for example A-B-A) can be read before or after the oligopeptide is cleaved from the support. This approach was used to construct a 24-member peptide library from 96 Microreactors and could be applicable to the synthesis of small organic molecule libraries as well.