Assessment of drug-induced mitochondrial dysfunction via altered cellular respiration and acidification measured in a 96-well platform

Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells

Min Wu, Andy Neilson, Amy L. Swift et al. · American Journal of Physiology-Cell Physiology · 2006 · 920 citations

Life Sciences, Cancer Biology, Oncology +17

High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening

Peter J. O’Brien, William Irwin, Dolores Diaz et al. · Archives of Toxicology · 2006 · 609 citations

Pharmacy, Pharmacology, Toxicology +16

Effect of Muraglitazar on Death and Major Adverse Cardiovascular Events in Patients With Type 2 Diabetes Mellitus

Steven E. Nissen · JAMA · 2005 · 555 citations

Medicine, Pharmacology, Pharmacotherapy +14

Mitochondrial damage: a possible mechanism of the “topical” phase of NSAID induced injury to the rat intestine

Siva G. Somasundaram, S Rafi, Jeremy Hayllar et al. · Gut · 1997 · 317 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

Importance of the bioenergetic reserve capacity in response to cardiomyocyte stress induced by 4-hydroxynonenal

Bradford G. Hill, Brian P. Dranka, Luyun Zou et al. · Biochemical Journal · 2009 · 286 citations · Full text

Life Sciences, Cardiology, Physiology +17