Concepedia

Simply combining fasudil and lipoic acid in a novel multitargeted chemical entity potentially useful in central nervous system disorders

Meihui Chen, Qi Liu, Anmin Liu, Min Tan, Asko Uri, Ziwei Chen, Guangye Huang, Yang Sun, Ge Hu, Peiqing Liu,

RSC Advances · 2014 · 19 citations · 13 references

DOI

Concepts

Abstract

A novel multifunctional ROCK inhibitor, L-F001, was synthesized and biologically evaluated as a potential drug for the treatment of CNS disorders.

References

13

Computational methods for the prediction of ‘drug-likeness’

David E. Clark, Stephen D. Pickett · Drug Discovery Today · 2000 · 573 citations

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Neuroprotective Actions of Methylene Blue and Its Derivatives

Ethan Poteet, Ali Winters, Liang‐Jun Yan et al. · PLoS ONE · 2012 · 148 citations · Full text

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Activation of RhoA/ROCK regulates NF-κB signaling pathway in experimental diabetic nephropathy

Xi Xie, Jing Peng, Xiuting Chang et al. · Molecular and Cellular Endocrinology · 2013 · 101 citations

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Discovery of novel N-substituted carbazoles as neuroprotective agents with potent anti-oxidative activity

Daqian Zhu, Meihui Chen, Min Li et al. · European Journal of Medicinal Chemistry · 2013 · 93 citations

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Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer’s disease

Michela Rosini, Elena Simoni, Manuela Bartolini et al. · European Journal of Medicinal Chemistry · 2011 · 88 citations · Full text

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