High-affinity bisubstrate probe for fluorescence anisotropy binding/displacement assays with protein kinases PKA and ROCK

Angela Vaasa, Indrek Viil, Erki Enkvist, +4

Analytical Biochemistry

BiochemistryProtein Kinases PkaHigh-affinity Bisubstrate ProbeChemical ProbeMolecular Recognition +3

Phosphorylation of Notch1 by Pim kinases promotes oncogenic signaling in breast and prostate cancer cells

Niina M. Santio, Sebastian K.-J. Landor, Laura Vahtera, +10

Oncotarget

Signal TransductionPim KinasesSignaling PathwayCell RegulationMedicine +9

Conjugation of Adenosine and Hexa-(<scp>d</scp>-arginine) Leads to a Nanomolar Bisubstrate-Analog Inhibitor of Basophilic Protein Kinases

Erki Enkvist, Darja Lavõgina, Gerda Raidaru, +5

Journal of Medicinal Chemistry

Protein-Induced Long Lifetime Luminescence of Nonmetal Probes

Erki Enkvist, Angela Vaasa, Marje Kasari, +5

ACS Chemical Biology

EngineeringLuminescence PropertyPhosphorescence ImagingLuminescence DonorBioimaging +17

[³⁵S]GTPγS autoradiography reveals a wide distribution of G_i/o‐linked ADP receptors in the nervous system: close similarities with the platelet <i>P2Y</i>_<i>ADP</i> receptor

Jarmo T. Laitinen, Asko Uri, Gerda Raidaru, +1

Journal of Neurochemistry

Surface-plasmon-resonance-based biosensor with immobilized bisubstrate analog inhibitor for the determination of affinities of ATP- and protein-competitive ligands of cAMP-dependent protein kinase

Kaido Viht, Sonja Schweinsberg, Marje Lust, +5

Analytical Biochemistry

Surface-plasmon-resonance-based BiosensorBiochemistryBioanalysisProtein-competitive LigandsChemical Probe +6

Novel galanin receptor ligands

Margus Pooga, Anders Juréus, Khadijeh Rezaei, +11

Journal of Peptide Research

A subnanomolar fluorescent probe for protein kinase CK2 interaction studies

Erki Enkvist, Kaido Viht, Nils Bischoff, +6

Organic & Biomolecular Chemistry

Drug TargetMolecular BiologyPeptide ScienceChemical BiologyPharmaceutical Chemistry +22

Adenosine-5′-carboxylic acid peptidyl derivatives as inhibitors of protein kinases

Mart Loog, Asko Uri, Gerda Raidaru, +2

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicinal ChemistryMedicineProtein KinasesPharmacology +3

Structural Analysis of ARC-Type Inhibitor (ARC-1034) Binding to Protein Kinase A Catalytic Subunit and Rational Design of Bisubstrate Analogue Inhibitors of Basophilic Protein Kinases

Darja Lavõgina, Marje Lust, Indrek Viil, +6

Journal of Medicinal Chemistry