Pim-selective inhibitor DHPCC-9 reveals Pim kinases as potent stimulators of cancer cell migration and invasion

Niina M. Santio, Riitta L. Vahakoski, Eeva-Marja Rainio, +6

Molecular Cancer

Pim Kinases Promote Migration and Metastatic Growth of Prostate Cancer Xenografts

Niina M. Santio, Sini K. Eerola, Ilkka Paatero, +6

PLoS ONE

Phosphorylation of Notch1 by Pim kinases promotes oncogenic signaling in breast and prostate cancer cells

Niina M. Santio, Sebastian K.-J. Landor, Laura Vahtera, +10

Oncotarget

Signal TransductionPim KinasesSignaling PathwayCell RegulationMedicine +9

The PIM1 kinase promotes prostate cancer cell migration and adhesion via multiple signalling pathways

Niina M. Santio, Maria Salmela, Heidi Arola, +4

Experimental Cell Research

Perineural InvasionSignaling PathwayMultiple Signalling PathwaysReceptor Tyrosine KinasePim1 Kinase +7

Phosphorylation of NFATC1 at PIM1 target sites is essential for its ability to promote prostate cancer cell migration and invasion

Sini K. Eerola, Niina M. Santio, Sanni Rinne, +11

Cell Communication and Signaling

Use of copper(I) catalyzed azide alkyne cycloaddition (CuAAC) for the preparation of conjugated pyrrolo[2,3-a]carbazole Pim kinase inhibitors

Boris Letribot, Rufine Akué‐Gédu, Niina M. Santio, +7

European Journal of Medicinal Chemistry

Combinatorial ChemistryAzide Alkyne CycloadditionMedicinal ChemistryNatural SciencesMedicine +8

PIM1 accelerates prostate cancer cell motility by phosphorylating actin capping proteins

Niina M. Santio, Veera Vainio, Tuuli Hoikkala, +8

Cell Communication and Signaling

Tricyclic Benzo[cd]azulenes Selectively Inhibit Activities of Pim Kinases and Restrict Growth of Epstein-Barr Virus-Transformed Cells

Alexandros Kiriazis, Riitta L. Vahakoski, Niina M. Santio, +6

PLoS ONE

Pim KinasesChemoprevention StrategyImmunologyEpstein-barr Virus-transformed CellsAntiviral Drug +20

PIM-induced phosphorylation of Notch3 promotes breast cancer tumorigenicity in a CSL-independent fashion

Sebastian K.-J. Landor, Niina M. Santio, William B. Eccleshall, +11

Journal of Biological Chemistry

PIM kinases inhibit AMPK activation and promote tumorigenicity by phosphorylating LKB1

Kwan Long Mung, William B. Eccleshall, Niina M. Santio, +2

Cell Communication and Signaling