Infection and Immunity · 2002 · 112 citations · 17 references
Life SciencesImmunologyMolecular BiologyAdaptive ImmunityVaccine ImmunologyVaccinologyAdaptive Immune ResponsesBacterial ImmunologyHost Defense Against InfectionProtective ImmunityProtein DomainsVaccine Antigen DiscoveryAnthrax VaccinesGlutathione S-transferase ActivityImmunogenicity Correlates Of ProtectionMechanisms Of Vaccine-induced ProtectionPeptide EpitopesProtective Antigen IdentificationProtective AntigensProtective Epitope Identification
The immunogenicity and protective efficacy of overlapping regions of the protective antigen (PA) polypeptide, cloned and expressed as glutathione S-transferase fusion proteins, have been assessed. Results show that protection can be attributed to individual domains and imply that it is domain 4 which contains the dominant protective epitopes of PA.
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Crystal structure of the anthrax toxin protective antigen
Carlo Petosa, R. John Collier, Kurt R. Klimpel et al. · Nature · 1997 · 755 citations
Life Sciences, Biochemistry, Biology +14
Kurt R. Klimpel, Sean S. Molloy, Gary Thomas et al. · Proceedings of the National Academy of Sciences · 1992 · 459 citations