A Recombinant Carboxy-Terminal Domain of the Protective Antigen of <i>Bacillus anthracis</i> Protects Mice against Anthrax Infection

Abstract

The immunogenicity and protective efficacy of overlapping regions of the protective antigen (PA) polypeptide, cloned and expressed as glutathione S-transferase fusion proteins, have been assessed. Results show that protection can be attributed to individual domains and imply that it is domain 4 which contains the dominant protective epitopes of PA.