Self-assembling chimeric polypeptide–doxorubicin conjugate nanoparticles that abolish tumours after a single injection

A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.

Yasuhiro Matsumura, Hiroshi Maeda · PubMed · 1986 · 6.8K citations

Pathology, Cancer Biology, Cancer Chemotherapy +17

Block copolymer micelles for drug delivery: design, characterization and biological significance

Kazunori Kataoka, Atsushi Harada, Yukio Nagasaki · Advanced Drug Delivery Reviews · 2001 · 3.5K citations

Block Co-polymers, Engineering, Polymer-drug Conjugate +11

Adriamycin-Induced DNA Damage Mediated by Mammalian DNA Topoisomerase II

K M Tewey, Thomas C. Rowe, Liu Yang et al. · Science · 1984 · 1.5K citations

Dna Damage, Molecular Biology, Broken Phosphodiester Bond +16

Purification of recombinant proteins by fusion with thermally-responsive polypeptides

Dan E. Meyer, Ashutosh Chilkoti · Nature Biotechnology · 1999 · 903 citations

Recombinant Proteins, Protein Folding, Protein Engineering +3

Block copolymer micelles as vehicles for drug delivery

Kazunori Kataoka, Kwon Glenn S., M. Yokoyama et al. · Journal of Controlled Release · 1993 · 867 citations

Nanomedicine, Engineering, Medicine +8