Concepedia

Functional analysis and consequences of Mdm2 E3 ligase inhibition in human tumor cells

Mark Wade, Y C Li, Ayumu Matani, Simon M. G. Braun, Francesca Milanesi, Luo Wei Rodewald, Geoffrey M. Wahl

Oncogene · 2012 · 23 citations · 37 references

DOI

Concepts

References

37

Direct observation of individual endogenous protein complexes in situ by proximity ligation

Ola Söderberg, Mats Gullberg, Malin Jarvius et al. · Nature Methods · 2006 · 2.4K citations

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Mdm2 Is a RING Finger-dependent Ubiquitin Protein Ligase for Itself and p53

Shengyun Fang, Jane P. Jensen, Robert L. Ludwig et al. · Journal of Biological Chemistry · 2000 · 1K citations · Full text

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The RING Heterodimer BRCA1-BARD1 Is a Ubiquitin Ligase Inactivated by a Breast Cancer-derived Mutation

Rintaro Hashizume, Mamoru Fukuda, Ichiro Maeda et al. · Journal of Biological Chemistry · 2001 · 638 citations · Full text

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SUMO‐1 modification activates the transcriptional response of p53

Manuel S. Rodríguez, Joana Desterro, Carol Midgley et al. · The EMBO Journal · 1999 · 634 citations

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Accelerated MDM2 auto‐degradation induced by DNA‐damage kinases is required for p53 activation

Jayne M. Stommel, Geoffrey M. Wahl · The EMBO Journal · 2004 · 390 citations · Full text

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