Concepedia

Phase I study of the combination of topotecan and irinotecan in children with refractory solid tumors

Carlos Rodríguez‐Galindo, Kristine R. Crews, Clinton F. Stewart, Wayne L. Furman, John C. Panetta, Najat C. Daw, Alvida M. Cain, Ming Tan, Peter Houghton, Victor M. Santana

Cancer Chemotherapy and Pharmacology · 2005 · 22 citations · 56 references

DOI

Concepts

References

56

Plant Antitumor Agents. I. The Isolation and Structure of Camptothecin, a Novel Alkaloidal Leukemia and Tumor Inhibitor from Camptotheca acuminata<sup>1,2</sup>

Monroe E. Wall, Mansukh C. Wani, Clarence Cook et al. · Journal of the American Chemical Society · 1966 · 2.2K citations

, , +8

Randomised trial of irinotecan plus supportive care versus supportive care alone after fluorouracil failure for patients with metastatic colorectal cancer

David Cunningham, Seppo Pyrhönen, R.D. James et al. · The Lancet · 1998 · 1.3K citations

, , +13

Identification of mammalian DNA topoisomerase I as an intracellular target of the anticancer drug camptothecin.

Yaw Huei Hsiang, Leroy F. Liu · PubMed · 1988 · 844 citations

, , +12

Metabolic fate of irinotecan in humans: correlation of glucuronidation with diarrhea.

E Gupta, Timothy M. Lestingi, Rosemarie Mick et al. · PubMed · 1994 · 506 citations

, , +14

A program package for simulation and parameter estimation in pharmacokinetic systems

David Z. D’Argenio, Alan Schumitzky · Computer Programs in Biomedicine · 1979 · 472 citations

, , +16