Proteome mapping of overexpressed membrane‐enriched and cytosolic proteins in sodium antimony gluconate (SAG) resistant clinical isolate of <i>Leishmania donovani</i>

Abstract

This study for the first time provided a cumulative proteomic analysis of proteins overexpressed in drug resistant clinical isolates of L. donovani indicating their possible role in antimony resistance of the parasite. Identified proteins provide a vast field to be exploited for novel treatment strategies against VL such as cloning and overexpression of these targets to produce recombinant therapeutic/prophylactic proteins.