Concepedia

Regulatory T-Cell–Mediated Attenuation of T-Cell Responses to the NY-ESO-1 ISCOMATRIX Vaccine in Patients with Advanced Malignant Melanoma

Theo Nicholaou, Lisa M. Ebert, Ian D. Davis, Grant A. McArthur, Heather Jackson, Nektaria Dimopoulos, Bee Shin Tan, Eugene Maraskovsky, Lena Miloradovic, Wendie Hopkins,

Clinical Cancer Research · 2009 · 118 citations · 25 references

DOIFull text

Open access

Abstract

Our results point to a tumor-induced systemic immune suppression, showing a clear association between the stage of melanoma progression, the number of Treg in the blood, and the clinical and immunologic efficacy of the NY-ESO-1 ISCOMATRIX cancer vaccine.

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