Stereochemistry‐Activity Relationships in Olfaction. Odorants containing a proton donor/proton acceptor unit

Abstract

Abstract A novel class of odorants is described where the odor is associated with the interaction of two functional groups, one being an H‐donor (AH function), and the other an H ‐acceptor ( B function). Generally, odor occurs only if the distance between the two structural elements (AH/B system) is less than 3 Å. Bifunctional derivatives of the p ‐menthane and iridane series served as models for deriving this rule. The stereospecificity of odor perception was an important prerequisite for its establishment.