Concepedia

Rebamipide Suppresses Collagen‐Induced Arthritis Through Reciprocal Regulation of Th17/Treg Cell Differentiation and Heme Oxygenase 1 Induction

Su‐Jin Moon, Jin‐Sil Park, Yun‐Ju Woo, Mi‐Ae Lim, Sung‐Min Kim, Seon‐Yeong Lee, Eun‐Kyung Kim, Hee Jin Lee, Weon Sun Lee, Sang‐Hi Park,

Arthritis & Rheumatology · 2013 · 52 citations · 27 references

DOI

Abstract

The inhibitory effects of rebamipide on joint inflammation are associated with recovery from an imbalance between Th17 cells and Treg cells and with activation of an Nrf2/HO-1 antioxidant pathway.

References

27

Foxp3+CD25+CD4+ natural regulatory T cells in dominant self‐tolerance and autoimmune disease

Shimon Sakaguchi, Masahiro Ono, Ruka Setoguchi et al. · Immunological Reviews · 2006 · 1.5K citations · Full text

Suppression of Immune Induction of Collagen-Induced Arthritis in IL-17-Deficient Mice

Susumu Nakae, Aya Nambu, Katsuko Sudo et al. · The Journal of Immunology · 2003 · 1.3K citations · Full text

Compromised Function of Regulatory T Cells in Rheumatoid Arthritis and Reversal by Anti-TNFα Therapy

Michael R. Ehrenstein, J. Grimley Evans, Animesh Singh et al. · The Journal of Experimental Medicine · 2004 · 1.2K citations · Full text

Human interleukin-17: A T cell-derived proinflammatory cytokine produced by the rheumatoid synovium

Martine Chabaud, Jean Marc Durand, Nicolas C. Buchs et al. · Arthritis & Rheumatism · 1999 · 938 citations · Full text

Anti-inflammatory and Upper Gastrointestinal Effects of Celecoxib in Rheumatoid Arthritis

Lee S. Simon, Arthur L. Weaver, David Y. Graham et al. · JAMA · 1999 · 803 citations