Vascular Neuronal NO Synthase Is Selectively Upregulated by Platelet-Derived Growth Factor

Abstract

These results provide the first evidence that vascular nNOS expression is upregulated selectively in response to PDGF through the MEK/ERK pathway. Upregulated nNOS may play an important compensatory role under arteriosclerotic/inflammatory conditions associated with eNOS dysfunction to maintain vascular homeostasis.