Concepedia

Dominant Negative Effects

Dominant Negative Effects is a genetic phenomenon in which a mutant allele exerts a detrimental influence on the function of the wild-type allele, resulting in a loss or reduction of function even in the presence of a normal allele, thereby producing a phenotypic effect in heterozygotes that mimics a loss-of-function mutation in a dominant manner.

2.5K

Publications

223K

Citations

14.1K

Authors

2.3K

Institutions

Publications per year

2017–2026

205

Variants

Dominant Negative Effect

Parents

Publications

2.5K

Sequence and Characterization of a Coactivator for the Steroid Hormone Receptor Superfamily

Sergio A. Oñate, Sophia Y. Tsai, Ming‐Jer Tsai et al. · Science · 1995 · 2.4K citations

, , +17

Dissection of the Autophagosome Maturation Process by a Novel Reporter Protein, Tandem Fluorescent-Tagged LC3

Shunsuke Kimura, Takeshi Noda, Tamotsu Yoshimori · Autophagy · 2007 · 2.3K citations · Full text

, , +11

p63, a p53 Homolog at 3q27–29, Encodes Multiple Products with Transactivating, Death-Inducing, and Dominant-Negative Activities

Annie Yang, Mourad Kaghad, Yunmei Wang et al. · Molecular Cell · 1998 · 2.1K citations · Full text

, , +15

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

Ken Inoki, Yong Li, Tian Xu et al. · Genes & Development · 2003 · 1.9K citations · Full text

, , +15

Regulation of myostatin activity and muscle growth

Se‐Jin Lee, Alexandra C. McPherron · Proceedings of the National Academy of Sciences · 2001 · 1.6K citations · Full text

, , +17

1–5 of 2.5K

Authors

14.1K

  1. SC
    Sheue-yann Cheng

    National Cancer Institute, United States

    8 publications · 313 citations

    8

    h-index

  2. KC
    Krishna Chatterjee

    University of Cambridge, United Kingdom

    7 publications · 741 citations

    7

    h-index

  3. VM
    Vishva M. Dixit

    University of Michigan, United States

    6 publications · 3.8K citations

    6

    h-index

  4. RD
    Rik Derynck

    University of California, San Francisco, United States

    6 publications · 1.1K citations

    6

    h-index

  5. JL
    J. Larry Jameson

    Northwestern University, United States

    6 publications · 441 citations

    6

    h-index

1–5 of 14.1K

Institutions

2.3K

  1. Harvard University

    Cambridge, United States

    59 h-index

    338 publications

    59.4K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    58 h-index

    258 publications

    40.8K citations

  3. National Institutes of Health

    Bethesda, United States

    45 h-index

    281 publications

    30.7K citations

  4. Inserm

    Paris, France

    42 h-index

    370 publications

    25.1K citations

  5. The University of Tokyo

    Tokyo, Japan

    37 h-index

    150 publications

    12.2K citations

  6. Yale University

    New Haven, United States

    37 h-index

    149 publications

    19.4K citations

  7. Centre National de la Recherche Scientifique

    Paris, France

    36 h-index

    280 publications

    19.7K citations

  8. University of California, San Francisco

    San Francisco, United States

    35 h-index

    135 publications

    25.5K citations

1–8 of 2.3K

Venues

  1. Journal of Biological Chemistry

    JBC · 254 publications · 24K citations

    85

    h-index

  2. Molecular and Cellular Biology

    MCB · 128 publications · 15.1K citations

    74

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 116 publications · 17.5K citations

    73

    h-index

  4. Development

    80 publications · 10.6K citations

    55

    h-index

  5. PubMed

    Repository · 79 publications · 5.8K citations

    46

    h-index

1–5