Journal of Liposome Research · 2002 · 21 citations · 6 references
PharmacyOncologyPharmaceuticsDrug DeliveryDrug DesignTargeted Drug DeliveryAngiogenesisLigand-mediated TargetingLiposomal FormulationsLiposome-based DeliveryReceptor-mediated TargetingTargeting LigandsCancer Targeting LigandsIntegrin-binding LigandsLiposome Delivery SystemsLiposomesLong-circulating LiposomesTargeted LiposomesTumor Vasculature TargetingVascular Targeting
The development of liposomes targeted to angiogenic endothelial cells offers exciting prospects for intervention in cancer and inflammation. Several proteins are (strongly) over-expressed on angiogenic endothelial cells as compared to the quiescent endothelium, and could potentially serve as targets for site-specific drug delivery. In this contribution particular attention is given to the design of targeted long-circulating liposomes directed against the alpha v beta 3-integrin protein.
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