Angewandte Chemie International Edition · 2007 · 93 citations · 25 references
Life SciencesMedicinal ChemistryPharmacologyBiophysical ChemistryStructural BiologyStructure-activity RelationshipsCytoskeletal ArchitectureEnzyme InhibitionMacromolecular AssemblyMicrotubule-associated ProteinsMicrotubule-targeting AgentsStructure-activity Relationship AnalysisBinding Affinity To TubulinDrug Binding Sites On TubulinMicrotubule Stabilizers
Fits in a pocket: The binding mode of epothilone A (EpoA) to tubulin (see picture; rods: C gray, H white, N blue, O red, S yellow) is determined by NMR spectroscopy in aqueous solution. The results explain the existing structure–activity relationship data for epothilones with both native and mutant tubulins, and support the existence of a common pharmacophore for EpoA and paclitaxel.
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Structure of the αβ tubulin dimer by electron crystallography
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