Dual blockade of phosphatidylinositol 3′-kinase and mitogen-activated protein kinase pathways overcomes paclitaxel-resistance in colorectal cancer

Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours

David M. Berman, Sunil Karhadkar, Anirban Maitra et al. · Nature · 2003 · 1.3K citations

Gastrointestinal Oncology, Medicine, Gastroenterology +10

Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR

Mehran S. Neshat, Ingo K. Mellinghoff, Chris Tran et al. · Proceedings of the National Academy of Sciences · 2001 · 973 citations · Full text

The PTEN–PI3K pathway: of feedbacks and cross-talks

Arkaitz Carracedo, Pier Paolo Pandolfi · Oncogene · 2008 · 884 citations

Pten–pi3k Pathway, Signal Transduction, Signaling Pathway +5

Constitutive and inducible Akt activity promotes resistance to chemotherapy, trastuzumab, or tamoxifen in breast cancer cells.

Amy S. Clark, Kip A. West, Samantha A. Streicher et al. · PubMed · 2002 · 591 citations

Breast Oncology, Chemoprevention Strategy, Apoptosis +22

HER2/PI-3K/Akt activation leads to a multidrug resistance in human breast adenocarcinoma cells

Christiane Knuefermann, Yang Lü, Bolin Liu et al. · Oncogene · 2003 · 452 citations

Tumor Biology, Breast Oncology, Her2/pi-3k/akt Activation +10