Development of progesterone receptor antagonists from 1,2-dihydrochromeno[3,4-f]quinoline agonist pharmacophore

The synthesis and transition temperatures of some 4,4″-dialkyl- and 4,4″-alkoxyalkyl-1,1′ :4′,1″-terphenyls with 2,3- or 2′,3′-difluoro substituents and of their biphenyl analogues

G. W. Gray, Michael Hird, D. Lacey et al. · Journal of the Chemical Society Perkin Transactions 2 · 1989 · 241 citations

Natural Sciences, Chemistry, Materials Science +16

Potent nonsteroidal progesterone receptor agonists: Synthesis and SAR study of 6-aryl benzoxazines

Puwen Zhang, Eugene A. Terefenko, Andrew Fensome et al. · Bioorganic & Medicinal Chemistry Letters · 2002 · 117 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +11

6-Aryl-1,4-dihydro-benzo[<i>d</i>][1,3]oxazin- 2-ones:  A Novel Class of Potent, Selective, and Orally Active Nonsteroidal Progesterone Receptor Antagonists

Puwen Zhang, Eugene A. Terefenko, Andrew Fensome et al. · Journal of Medicinal Chemistry · 2002 · 106 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13

Mechanism of the Skraup and Doebner-von Miller quinoline syntheses. Cyclization of .alpha.,.beta.-unsaturated N-aryliminium salts via 1,3-diazetidinium ion intermediates

John J. Eisch, Tomasz Dluzniewski · The Journal of Organic Chemistry · 1989 · 99 citations

Natural Sciences, Chemistry, Medicinal Chemistry +7

5-Aryl-1,2-dihydrochromeno[3,4-<i>f</i>]quinolines:  A Novel Class of Nonsteroidal Human Progesterone Receptor Agonists

Lin Zhi, Christopher M. Tegley, E. Adam Kallel et al. · Journal of Medicinal Chemistry · 1998 · 65 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17