Concepedia

Toll-like receptor signaling adapter proteins govern spread of neuropathic pain and recovery following nerve injury in male mice

Jennifer A. Stokes, Jonathan Cheung, Kelly A. Eddinger, Maripat Corr, Tony L. Yaksh

Journal of Neuroinflammation · 2013 · 109 citations · 68 references

DOIFull text

Open access

Abstract

These observations suggest a critical role for the MyD88 pathway in initiating neuropathic pain, but a distinct role for the TRIF pathway and interferon in regulating neuropathic pain phenotypes in male mice.

References

68

Quantitative assessment of tactile allodynia in the rat paw

Sandra R. Chaplan, Flemming W. Bach, J W Pogrel et al. · Journal of Neuroscience Methods · 1994 · 7.7K citations

, , +11

Circulating mitochondrial DAMPs cause inflammatory responses to injury

Qin Zhang, Mustafa Raoof, Yu Chen et al. · Nature · 2010 · 3.6K citations · Full text

, , +6

Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the <i>Lps</i> Gene Product

Katsuaki Hoshino, Osamu Takeuchi, Taro Kawai et al. · The Journal of Immunology · 1999 · 3.4K citations · Full text

Differential Roles of TLR2 and TLR4 in Recognition of Gram-Negative and Gram-Positive Bacterial Cell Wall Components

Osamu Takeuchi, Katsuaki Hoshino, Taro Kawai et al. · Immunity · 1999 · 3.3K citations · Full text

, , +7

IRF-7 is the master regulator of type-I interferon-dependent immune responses

Kenya Honda, Hideyuki Yanai, Hideo Negishi et al. · Nature · 2005 · 2.2K citations

, , +11