Klotho Depletion Contributes to Increased Inflammation in Kidney of the <i>db/db</i> Mouse Model of Diabetes via RelA (Serine)536 Phosphorylation

Abstract

These findings suggest that Klotho serves as an anti-inflammatory modulator, negatively regulating the production of NF-κB-linked inflammatory proteins via a mechanism that involves phosphorylation of Ser(536) in the transactivation domain of RelA.