Concepedia

Publication | Open Access

Dexmedetomidine provides renoprotection against ischemia-reperfusion injury in mice

DOIFull Paper Access

277

Citations

28

References

2011

Year

Jianteng Gu, Pamela Sun, Hailin Zhao, Helena Watts, Robert D. Sanders, Niccolò Terrando, Peiyuan Xia, Mervyn Maze, Daqing Ma
Critical Care

Abstract

Our data suggest that Dex likely activates cell survival signal pAKT via α2 adrenoceptors to reduce cell death and HMGB1 release and subsequently inhibits TLR4 signaling to provide reno-protection.

References

YearCitations

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