Concepedia

Synthesis of novel celecoxib analogues by bioisosteric replacement of sulfonamide as potent anti-inflammatory agents and cyclooxygenase inhibitors

Nisha Chandna, Satish Kumar, Pawan Kaushik, Dhirender Kaushik, Somendu Kumar Roy, Girish Kumar Gupta, Sanjay M. Jachak, Jitander K. Kapoor, Pawan K. Sharma

Bioorganic & Medicinal Chemistry · 2013 · 69 citations · 25 references

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25

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

John R. Vane · Nature New Biology · 1971 · 8.6K citations

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Carrageenin-Induced Edema in Hind Paw of the Rat as an Assay for Antiinflammatory Drugs

C. A. Winter, Edwin A. Risley, George W. Nuss · Experimental Biology and Medicine · 1962 · 5.7K citations

, , +7

MolDock:  A New Technique for High-Accuracy Molecular Docking

René Thomsen, Mikael H. Christensen · Journal of Medicinal Chemistry · 2006 · 2.3K citations

, , +16

Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors:  Identification of 4-[5-(4-Methylphenyl)-3- (trifluoromethyl)-1<i>H</i>-pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib)

Thomas D. Penning, John J. Talley, Stephen R. Bertenshaw et al. · Journal of Medicinal Chemistry · 1997 · 2K citations · Full text

, , +17

Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing.

Wei Xie, Jeffrey G. Chipman, Donald Robertson et al. · Proceedings of the National Academy of Sciences · 1991 · 1.7K citations

, , +16