Tumor Necrosis Factor‐α and Apoptosis Signal‐Regulating Kinase 1 Control Reactive Oxygen Species Release, Mitochondrial Autophagy and C‐Jun N‐Terminal Kinase/P38 Phosphorylation During Necrotizing Enterocolitis

Abstract

Our findings suggest that TNF-alpha induces significant mitochondrial dysfunction and activation of mitochondrial apoptotic responses, leading to intestinal epithelial cell apoptosis during NEC. Therapies directed against mitochondria/ROS may provide important therapeutic options, as well as ameliorate intestinal epithelial cell apoptosis during NEC.