Concepedia

n-3 polyunsaturated fatty acids stimulate osteoclastogenesis through PPARγ-mediated enhancement of c-Fos expression, and suppress osteoclastogenesis through PPARγ-dependent inhibition of NFkB activation

Atsuko Nakanishi, Ikuyo Tsukamoto

The Journal of Nutritional Biochemistry · 2015 · 44 citations · 40 references

DOI

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References

40

Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor

Peter Tontonoz, Erding Hu, Bruce M. Spiegelman · Cell · 1994 · 3.5K citations

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c-Fos: a Key Regulator of Osteoclast-Macrophage Lineage Determination and Bone Remodeling

Agamemnon E. Grigoriadis, Zhao‐Qi Wang, Marco Cecchini et al. · Science · 1994 · 1.3K citations

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Birth and Death of Bone Cells: Basic Regulatory Mechanisms and Implications for the Pathogenesis and Treatment of Osteoporosis

Stavros C. Manolagas · Endocrine Reviews · 2000 · 1.3K citations

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A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-γ

Gabriel Pascual, Amy L. Fong, Sumito Ogawa et al. · Nature · 2005 · 1.2K citations · Full text

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Origin of osteoclasts: mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells.

Nobuyuki Udagawa, N. Takahashi, Takuhiko Akatsu et al. · Proceedings of the National Academy of Sciences · 1990 · 1K citations

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