Facile axial chirality control by using a precursor with central chirality. Application to the preparation of new axially chiral diphosphine complexes for asymmetric catalysis

Abstract

A diastereoselective synthesis of a new chiral diphosphine with planar chirality is performed in 2 steps from (S)-p-tolylferrocenyl sulfoxide with 60% overall yield. The ligand gives enantioselectivities up to 98% ee in Pd(0)-catalyzed allylic substitution reactions.