The Metabolism and Disposition of the Oral Direct Thrombin Inhibitor, Dabigatran, in Humans

The Pharmacology and Management of the Vitamin K Antagonists

Jack Ansell, Jack Hirsh, L. Poller et al. · CHEST Journal · 2004 · 1.5K citations

Medicine, Pharmacology, Pharmacotherapy +9

The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects

Joachim Stangier, Karin Rathgen, Hildegard Stähle et al. · British Journal of Clinical Pharmacology · 2007 · 884 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +17

Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism.

F. Peter Guengerich, M V Martin, Philippe Beaune et al. · Journal of Biological Chemistry · 1986 · 730 citations · Full text

Medicine, Biochemistry, Pharmacology +17

Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.

Deborah J. Newton, R W Wang, Anthony Y.H. Lu · Drug Metabolism and Disposition · 1995 · 606 citations

Medicine, Pharmacokinetics, Pharmacology +17

Structure-Based Design of Novel Potent Nonpeptide Thrombin Inhibitors

Norbert Hauel, Herbert Nar, Henning Priepke et al. · Journal of Medicinal Chemistry · 2002 · 451 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16