Concepedia

Farnesoid X receptor agonists attenuate colonic epithelial secretory function and prevent experimental diarrhoea in vivo

Magdalena S. Mroz, Niamh Keating, Joseph B. J. Ward, Rafiquel Sarker, Gabriella Aviello, Mark Donowitz, Padraic G. Fallon, Stephen J. Keely

Gut · 2013 · 76 citations · 36 references

DOI

Abstract

These data reveal a novel antisecretory role for the FXR in colonic epithelial cells and suggest that FXR agonists have excellent potential for development as a new class of antidiarrheal drugs.

References

36

Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease

Raffaella Maria Gadaleta, Karel J. van Erpecum, Bas Oldenburg et al. · Gut · 2011 · 827 citations

Colonic Secretion of Water and Electrolytes Induced by Bile Acids: Perfusion Studies in Man

Hagop S. Mekhjian, Sidney F. Phillips, Alan F. Hofmann · Journal of Clinical Investigation · 1971 · 579 citations · Full text

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Identification of a Chemical Tool for the Orphan Nuclear Receptor FXR

Patrick Maloney, Derek J. Parks, Curt D. Haffner et al. · Journal of Medicinal Chemistry · 2000 · 521 citations · Full text

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Cystic Fibrosis Heterozygote Resistance to Cholera Toxin in the Cystic Fibrosis Mouse Model

Sherif E. Gabriel, Kristen Brigman, Beverly H. Koller et al. · Science · 1994 · 484 citations

Mast cells are required for experimental oral allergen–induced diarrhea

Eric B. Brandt, Richard T. Strait, Dan Hershko et al. · Journal of Clinical Investigation · 2003 · 404 citations · Full text