A Selective p38α Mitogen-Activated Protein Kinase Inhibitor Reverses Cartilage and Bone Destruction in Mice with Collagen-Induced Arthritis

Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis.

Richard Williams, Marc Feldmann, R N Maini · Proceedings of the National Academy of Sciences · 1992 · 986 citations

Medicine, Immunology, Pathobiology +12

Recombinant Human Parathyroid Hormone (1–34) [Teriparatide] Improves Both Cortical and Cancellous Bone Structure

Yebin Jiang, Jenny Zhao, Bruce Mitlak et al. · Journal of Bone and Mineral Research · 2003 · 625 citations

Medicine, Orthopaedic Surgery, Orthopedic Surgery +17

Anticytokine treatment of established type II collagen-induced arthritis in DBA/1 mice: A comparative study using anti-TNFα, anti-IL-1α/β and IL-1Ra

Leo A. B. Joosten, Monique M. Helsen, Fons A. J. van de Loo et al. · Arthritis & Rheumatism · 2008 · 506 citations

Medicine, Immunology, Pharmacotherapy +17

Novel Homologues of CSBP/p38 MAP Kinase: Activation, Substrate Specificity and Sensitivity to Inhibition by Pyridinyl Imidazoles

Sanjay Kumar, Peter McDonnell, Rebecca J. Gum et al. · Biochemical and Biophysical Research Communications · 1997 · 505 citations

Life Sciences, Cell Biology, Molecular Biology +14

Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function.

A M Badger, Jeremy N. Bradbeer, Bartholomew J. Votta et al. · Journal of Pharmacology and Experimental Therapeutics · 1996 · 499 citations

Medicine, Immunology, Pharmacology +17