Concepedia

Binding of Tritiated Sildenafil, Tadalafil, or Vardenafil to the Phosphodiesterase-5 Catalytic Site Displays Potency, Specificity, Heterogeneity, and cGMP Stimulation

Mitsi A. Blount, Alfreda Beasley, Roya Zoraghi, Konjeti R. Sekhar, Emmanuel P. Bessay, Sharron H. Francis, Jackie D. Corbin

Molecular Pharmacology · 2004 · 175 citations · 39 references

DOI

Concepts

References

39

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

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EFFECTS OF SILDENAFIL ON THE RELAXATION OF HUMAN CORPUS CAVERNOSUM TISSUE IN VITRO AND ON THE ACTIVITIES OF CYCLIC NUCLEOTIDE PHOSPHODIESTERASE ISOZYMES

Stephen A. Ballard, Clive Gingell, Kim Tang et al. · The Journal of Urology · 1998 · 589 citations

, , +6

The GAF domain: an evolutionary link between diverse phototransducing proteins

L. Aravind, Chris P. Ponting · Trends in Biochemical Sciences · 1997 · 573 citations

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Purification and characterization of a cyclic GMP-stimulated cyclic nucleotide phosphodiesterase from bovine tissues.

Timothy J. Martins, Marc C. Mumby, Joseph A. Beavo · Journal of Biological Chemistry · 1982 · 324 citations · Full text

, , +17

Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules

B.-J. Sung, Kwang Yeon Hwang, Young Ho Jeon et al. · Nature · 2003 · 278 citations

, , +16