High lung PDE5: A strong basis for treating pulmonary hypertension with PDE5 inhibitors

Jackie D. Corbin, Alfreda Beasley, Mitsi A. Blount, +1

Biochemical and Biophysical Research Communications

HypertensionPulmonary Arterial HypertensionPulmonary CirculationDrug DiscoveryPharmacology +9

Binding of Tritiated Sildenafil, Tadalafil, or Vardenafil to the Phosphodiesterase-5 Catalytic Site Displays Potency, Specificity, Heterogeneity, and cGMP Stimulation

Mitsi A. Blount, Alfreda Beasley, Roya Zoraghi, +4

Molecular Pharmacology

miR-23a is decreased during muscle atrophy by a mechanism that includes calcineurin signaling and exosome-mediated export

Matthew B. Hudson, Myra E. Woodworth‐Hobbs, Bin Zheng, +5

American Journal of Physiology-Cell Physiology

Muscle FunctionEngineeringSkeletal Muscle AtrophyCellular PhysiologyMuscle Atrophy +16

Vardenafil: structural basis for higher potency over sildenafil in inhibiting cGMP-specific phosphodiesterase-5 (PDE5)

Jackie D. Corbin, Alfreda Beasley, Mitsi A. Blount, +1

Neurochemistry International

Molecular PharmacologyMedicinal ChemistryHigher PotencyMedicineDrug Discovery +4

Phosphorylation of UT-A1 urea transporter at serines 486 and 499 is important for vasopressin-regulated activity and membrane accumulation

Mitsi A. Blount, Abinash C. Mistry, Otto Fröhlich, +4

American Journal of Physiology-Renal Physiology

Protein SecretionMembrane AccumulationSerines 486Cellular PhysiologySerine 486 +18

Vasopressin Increases Plasma Membrane Accumulation of Urea Transporter UT-A1 in Rat Inner Medullary Collecting Ducts

Janet D. Klein, Otto Fröhlich, Mitsi A. Blount, +3

Journal of the American Society of Nephrology

Forskolin stimulates phosphorylation and membrane accumulation of UT-A3

Mitsi A. Blount, Janet D. Klein, Christopher F. Martin, +2

American Journal of Physiology-Renal Physiology

Protein SecretionCytoskeletonMembrane AccumulationCellular PhysiologyRat Imcd +16

[3H]Sildenafil Binding to Phosphodiesterase-5 Is Specific, Kinetically Heterogeneous, and Stimulated by cGMP

Jackie D. Corbin, Mitsi A. Blount, James L. Weeks, +7

Molecular Pharmacology

Collecting duct-specific knockout of adenylyl cyclase type VI causes a urinary concentration defect in mice

Karl Roos, Kevin A. Strait, Kalani L. Raphael, +2

American Journal of Physiology-Renal Physiology

Urinary Concentration DefectWater HomeostasisRenal FunctionPlasma Avp LevelsChronic Kidney Disease +16

Metformin, an AMPK activator, stimulates the phosphorylation of aquaporin 2 and urea transporter A1 in inner medullary collecting ducts

Janet D. Klein, Yanhua Wang, Mitsi A. Blount, +4

American Journal of Physiology-Renal Physiology

Ampk ActivatorRenal InflammationUrea Transporter A1Cellular PhysiologyMolecular Pharmacology +26