Early structural changes in cartilage and bone are required for the attachment and invasion of inflamed synovial tissue during destructive inflammatory arthritis

Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis.

Jeanne Keffer, Lesley Probert, Haris Cazlaris et al. · The EMBO Journal · 1991 · 1.7K citations · Full text

Life Sciences, Genetics, Immunology +14

Production of Mice Deficient in Genes for Interleukin (IL)-1α, IL-1β, IL-1α/β, and IL-1 Receptor Antagonist Shows that IL-1β Is Crucial in Turpentine-induced Fever Development and Glucocorticoid Secretion

Reiko Horai, Masahide Asano, Katsuko Sudo et al. · The Journal of Experimental Medicine · 1998 · 615 citations · Full text

Life Sciences, Immunology, Physiology +16

IL-1 alpha beta blockade prevents cartilage and bone destruction in murine type II collagen-induced arthritis, whereas TNF-alpha blockade only ameliorates joint inflammation.

Leo A. B. Joosten, M.M. Helsen, Tore Saxne et al. · PubMed · 1999 · 442 citations

Medicine, Immunology, Pharmacology +17

Delayed wound repair and impaired angiogenesis in mice lacking syndecan-4

Frank Echtermeyer, Michael Streit, Sarah A. Wilcox‐Adelman et al. · Journal of Clinical Investigation · 2001 · 427 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

IL-1αβ Blockade Prevents Cartilage and Bone Destruction in Murine Type II Collagen-Induced Arthritis, Whereas TNF-α Blockade Only Ameliorates Joint Inflammation

Leo A. B. Joosten, Monique M. Helsen, Tore Saxne et al. · The Journal of Immunology · 1999 · 397 citations · Full text

Medicine, Immunology, Pharmacology +17