The Substrate-Activity-Screening methodology applied to receptor tyrosine kinases: A proof-of-concept study

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Medicine, Medicinal Chemistry, Pharmacology +13

The specificities of protein kinase inhibitors: an update

Jenny Bain, Hilary McLauchlan, Matthew Elliott et al. · Biochemical Journal · 2003 · 1.4K citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +11

Fragment-Based Substrate Activity Screening Method for the Identification of Potent Inhibitors of the <i>Mycobacterium tuberculosis</i> Phosphatase PtpB

Matthew B. Soellner, Katherine A. Rawls, Christoph Grundner et al. · Journal of the American Chemical Society · 2007 · 106 citations · Full text

Life Sciences, Biochemistry, Medicinal Chemistry +17

A Generic, Homogenous Method for Measuring Kinase and Inhibitor Activity via Adenosine 5´-Diphosphate Accumulation

Neil W. Charter, Lindy Kauffman, Raj Singh et al. · SLAS DISCOVERY · 2006 · 75 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Discovery of a Novel Series of Potent and Selective Substrate-Based Inhibitors of p60<i>^c</i><i>^-</i><i>^src</i> Protein Tyrosine Kinase:  Conformational and Topographical Constraints in Peptide Design

Josue Alfaro-Lopez, Wei Yuan, Brigitte C. Phan et al. · Journal of Medicinal Chemistry · 1998 · 53 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17