Metabolism of the c-Fos/Activator Protein-1 Inhibitor T-5224 by Multiple Human UDP-Glucuronosyltransferase Isoforms

Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes.

Lalitha Iyer, Christopher D. King, P. F. Whitington et al. · Journal of Clinical Investigation · 1998 · 680 citations · Full text

Medicine, Oncology, Pharmacology +17

Determination of mRNA Expression of Human UDP-Glucuronosyltransferases and Application for Localization in Various Human Tissues by Real-Time Reverse Transcriptase-Polymerase Chain Reaction

Shuji Ohno, Shizuo Nakajin · Drug Metabolism and Disposition · 2008 · 425 citations

Life Sciences, Biochemistry, Molecular Biology +13

In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model

J. Brian Houston, Kathryn E. Kenworthy · Drug Metabolism and Disposition · 2000 · 392 citations

Pharmacy, Pharmacokinetics, Pharmacology +17

Common Human UGT1A Polymorphisms and the Altered Metabolism of Irinotecan Active Metabolite 7-Ethyl-10-hydroxycamptothecin (SN-38)

Jean-François Gagné, Valérie Montminy, Patrick Bélanger et al. · Molecular Pharmacology · 2002 · 341 citations

Medicine, Biochemistry, Pharmacology +14

Expression of UGT1A and UGT2B mRNA in Human Normal Tissues and Various Cell Lines

Akiko Nakamura, Miki Nakajima, Hiroyuki Yamanaka et al. · Drug Metabolism and Disposition · 2008 · 284 citations

Medicine, Pharmacology, Drug Metabolism +8