FUNCTIONAL CHARACTERIZATION OF FIVE NOVEL CYP2C8 VARIANTS, G171S, R186X, R186G, K247R, AND K383N, FOUND IN A JAPANESE POPULATION

Substrate recognition sites in cytochrome P450 family 2 (CYP2) proteins inferred from comparative analyses of amino acid and coding nucleotide sequences.

Osamu Gotoh · Journal of Biological Chemistry · 1992 · 1.2K citations · Full text

Structural Bioinformatics, Biomolecular Structure Prediction, Signal Recognition +17

Polymorphisms in human CYP2C8 decrease metabolism of the anticancer drug paclitaxel and arachidonic acid

Ding Dai, Darryl C. Zeldin, Joyce Blaisdell et al. · Pharmacogenetics · 2001 · 497 citations

Anticancer Drug Paclitaxel, Aldehyde Dehydrogenase, Biochemistry +14

Selective biotransformation of taxol to 6 alpha-hydroxytaxol by human cytochrome P450 2C8.

Atiqur Rahman, Ken Korzekwa, James Grogan et al. · PubMed · 1994 · 391 citations

Pharmaceutical Science, Pharmaceutical Chemistry, Aldehyde Dehydrogenase +15

Structure of Human Microsomal Cytochrome P450 2C8

G. Schoch, Jason K. Yano, Michael R. Wester et al. · Journal of Biological Chemistry · 2004 · 381 citations · Full text

CYP2C8 polymorphisms in Caucasians and their relationship with paclitaxel 6α-hydroxylase activity in human liver microsomes

Namrata Bahadur, Julian Leathart, Elaine Mutch et al. · Biochemical Pharmacology · 2002 · 237 citations

Medicine, Liver Physiology, Human Polymorphism +10