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Structure-based design of oxygen-linked macrocyclic kinase inhibitors: discovery of SB1518 and SB1578, potent inhibitors of Janus kinase 2 (JAK2) and Fms-like tyrosine kinase-3 (FLT3)

Medicinal ChemistryFms-like Tyrosine Kinase-3Natural SciencesDrug DiscoveryMedicineRational Drug DesignJanus Kinase 2Receptor Tyrosine KinaseMechanism Of ActionStructure-based DesignAnti-cancer AgentChemical BiologyPharmacologyNovel TherapyBiomolecular Engineering