Evelyn Tan

Discovery of the Macrocycle 11-(2-Pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene (SB1518), a Potent Janus Kinase 2/Fms-Like Tyrosine Kinase-3 (JAK2/FLT3) Inhibitor for the Treatment of Myelofibrosis and Lymphoma

Anthony D. William, Angeline C.-H. Lee, Stéphanie Blanchard et al. · Journal of Medicinal Chemistry · 2011 · 198 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Discovery of the Macrocycle (9<i>E</i>)-15-(2-(Pyrrolidin-1-yl)ethoxy)-7,12,25-trioxa-19,21,24-triaza-tetracyclo[18.3.1.1(2,5).1(14,18)]hexacosa-1(24),2,4,9,14(26),15,17,20,22-nonaene (SB1578), a Potent Inhibitor of Janus Kinase 2/Fms-LikeTyrosine Kinase-3 (JAK2/FLT3) for the Treatment of Rheumatoid Arthritis

Anthony D. William, Angeline C.-H. Lee, Anders Poulsen et al. · Journal of Medicinal Chemistry · 2012 · 52 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Structure-based design of oxygen-linked macrocyclic kinase inhibitors: discovery of SB1518 and SB1578, potent inhibitors of Janus kinase 2 (JAK2) and Fms-like tyrosine kinase-3 (FLT3)

Anders Poulsen, Anthony D. William, Stéphanie Blanchard et al. · Journal of Computer-Aided Molecular Design · 2012 · 42 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

Structure-based design of nitrogen-linked macrocyclic kinase inhibitors leading to the clinical candidate SB1317/TG02, a potent inhibitor of cyclin dependant kinases (CDKs), Janus kinase 2 (JAK2), and Fms-like tyrosine kinase-3 (FLT3)

Anders Poulsen, Anthony D. William, Stéphanie Blanchard et al. · Journal of Molecular Modeling · 2012 · 37 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

Synthesis and evaluation of alkenyl indazoles as selective Aurora kinase inhibitors

Stéphanie Blanchard, Anthony D. William, Angeline C.-H. Lee et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 17 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +10