Chiral Monophosphites Derived from Carbohydrate: Conformational Effect in Catalytic Asymmetric Hydrogenation

Abstract

[reaction: see text]. The carbohydrate-derived chiral monophosphites with additional groups have been synthesized and used for asymmetric hydrogenation of dimethyl itaconate and enamides. Up to 99.6% ee and 98.5% ee have been obtained, respectively.