Concepedia

Highly Enantioselective Rh-Catalyzed Hydrogenation Reactions Based on Chiral Monophosphite Ligands

Manfred T. Reetz, Gerlinde Mehler

Angewandte Chemie International Edition · 2000 · 371 citations · 9 references

DOI

Concepts

Abstract

Excellent ligands in the Rh-catalyzed hydrogenation of olefins (ee>95 %) are the monophosphites 1 derived from BINOL. Thus, the notion that only chelating ligands lead to high enantioselectivities in these reactions no longer pertains.

References

9

Asymmetric catalysis in organic synthesis

European Journal of Medicinal Chemistry · 1994 · 2K citations

, , +14

Asymmetric catalysis in organic synthesis

G. Jenner · Applied Catalysis A General · 1994 · 1.8K citations

, , +14

Synthesis of 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl (BINAP), an atropisomeric chiral bis(triaryl)phosphine, and its use in the rhodium(I)-catalyzed asymmetric hydrogenation of .alpha.-(acylamino)acrylic acids

Akira Miyashita, Arisa Yasuda, Hidemasa Takaya et al. · Journal of the American Chemical Society · 1980 · 999 citations

, , +10

Asymmetric hydrogenation with a complex of rhodium and a chiral bisphosphine

William S. Knowles, M. J. Sabacky, B. D. Vineyard et al. · Journal of the American Chemical Society · 1975 · 434 citations

, , +8

The asymmetric synthesis of hydratropic acid and amino-acids by homogeneous catalytic hydrogenation

T. P. DANG, Henri B. Kagan · Journal of the Chemical Society D Chemical Communications · 1971 · 397 citations

, , +12