Design of a Long Acting Peptide Functioning as Both a Glucagon-like Peptide-1 Receptor Agonist and a Glucagon Receptor Antagonist

Abstract

The closely related peptides glucagon-like peptide (GLP-1) and glucagon have opposing effects on blood glucose. GLP-1 induces glucose-dependent insulin secretion in the pancreas, whereas glucagon stimulates gluconeogenesis and glycogenolysis in the liver. The identification of a hybrid peptide acting as both a GLP-1 agonist and a glucagon antagonist would provide a novel approach the of a of hybrid peptides of glucagon and GLP-1 a GLP-1 peptides both the GLP-1 and glucagon The of glucagon the the and the peptide a peptide the novel of as both a GLP-1 agonist and a glucagon the of peptide in GLP-1 agonist and glucagon antagonist of the the in of the peptide the of in have a novel peptide as a The closely related peptides glucagon-like peptide (GLP-1) and glucagon have opposing effects on blood glucose. GLP-1 induces glucose-dependent insulin secretion in the pancreas, whereas glucagon stimulates gluconeogenesis and glycogenolysis in the liver. 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