Concepedia

Inhibition of the PI3K-Akt Signaling Pathway Reduces Tumor Necrosis Factor-α Production in Response to Titanium Particles in Vitro

Matthew V. Smith, Michael J. Lee, Andrew S. Islam, Jacqueline L. Rohrer, Victor M. Goldberg, Michelle Beidelschies, Edward M. Greenfield

Journal of Bone and Joint Surgery · 2007 · 66 citations · 34 references

DOI

Abstract

Inhibition of the PI3K-Akt pathway reduces macrophage TNF-alpha production in response to titanium particles with adherent endotoxin and endotoxin-free particles in vitro.

References

34

Specificity and mechanism of action of some commonly used protein kinase inhibitors

Stephen Davies, Helen Reddy, Matilde Caivano et al. · Biochemical Journal · 2000 · 4.1K citations · Full text

Drug Target, Pharmacotherapy, Pharmaceutical Chemistry +17

Specificity and mechanism of action of some commonly used protein kinase inhibitors

Stephen Davies, Helen Reddy, Matilde Caivano et al. · Biochemical Journal · 2000 · 3.1K citations

Drug Target, Pharmacotherapy, Pharmaceutical Chemistry +17

Blockade of PI3Kγ suppresses joint inflammation and damage in mouse models of rheumatoid arthritis

Montserrat Camps, Thomas Rückle, Hong Ji et al. · Nature Medicine · 2005 · 742 citations

Immunology, Immune Regulation, Cell Death +16

Antibodies to cachectin/tumor necrosis factor reduce interleukin 1 beta and interleukin 6 appearance during lethal bacteremia.

Yuman Fong, Kevin J. Tracey, Lyle L. Moldawer et al. · The Journal of Experimental Medicine · 1989 · 644 citations · Full text

Microbial Pathogens, Humoral Response, Immunology +18

Proliferative Defect and Embryonic Lethality in Mice Homozygous for a Deletion in the p110α Subunit of Phosphoinositide 3-Kinase

Lei Bi, Ichiro Okabe, David J. Bernard et al. · Journal of Biological Chemistry · 1999 · 444 citations · Full text