Fatty Acid Composition of Cerebrosides and Phospholipids in Brains of Undernourished Rats

Abstract

The effect of undernutrition on the fatty acid profiles of cerebrosides and phospholipids in the developing rat brain has been investigated. Undernutrition was imposed post-natally in pups by the method of large litter size and feeding a protein-deficient diet during the post-weaning period. The results showed that lignoceric (24:0) and nervonic (24:1) acids of cerebrosides, which are marker fatty acids of myelin, were significantly lower in 50-day-old undernourished rats than in well-nourished controls. Among the polyunsaturated fatty acids of phospholipids the contribution of arachidonic acid (20:4) to the total fatty acids was lower in 10- and 21-day-old as well as 50-day-old rats. Altered fatty acid pattern of lipid classes might be the result of impaired myelination of brain due to nutritional stress.