Concepedia

Huntingtin proteolysis releases non‐polyQ fragments that cause toxicity through dynamin 1 dysregulation

Marie‐Thérèse El‐Daher, Emilie Hangen, Julie Bruyère, Ghislaine Poizat, Ismael Al‐Ramahi, Raúl Pardo, Nicolas Bourg, Sylvie Souquère, Céline Mayet, Gérard Pierron,

The EMBO Journal · 2015 · 102 citations · 52 references

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52

Exon 1 of the HD Gene with an Expanded CAG Repeat Is Sufficient to Cause a Progressive Neurological Phenotype in Transgenic Mice

Laura Mangiarini, Kirupa Sathasivam, Mary J. Seller et al. · Cell · 1996 · 3.1K citations · Full text

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Huntingtin Acts in the Nucleus to Induce Apoptosis but Death Does Not Correlate with the Formation of Intranuclear Inclusions

Frédéric Saudou, Steven Finkbeiner, Didier Devys et al. · Cell · 1998 · 1.6K citations · Full text

, , +12

Polyglutamine expansion as a pathological epitope in Huntington's disease and four dominant cerebellar ataxias

Yvon Trottier, Yves Lutz, Giovanni Stévanin et al. · Nature · 1995 · 654 citations

, , +12

Cleavage at the Caspase-6 Site Is Required for Neuronal Dysfunction and Degeneration Due to Mutant Huntingtin

Rona K. Graham, Yu Deng, Elizabeth Slow et al. · Cell · 2006 · 649 citations · Full text

, , +15

Dominant phenotypes produced by the HD mutation in STHdhQ111 striatal cells

Flavia Trettel · Human Molecular Genetics · 2000 · 620 citations · Full text

, , +17