Concepedia

Crystal structure and substrate-binding mode of the mycoestrogen-detoxifying lactonase ZHD from Clonostachys rosea

Wei Peng, Tzu‐Ping Ko, Yunyun Yang, Yingying Zheng, Chun‐Chi Chen, Zhen Zhu, Chun‐Hsiang Huang, Yi‐Fang Zeng, Jian‐Wen Huang, Andrew H.‐J. Wang,

RSC Advances · 2014 · 52 citations · 10 references

DOI

Concepts

Abstract

The mycotoxin zearalenone binds to a deep pocket of the dimeric lactonase in a bent conformation, revealing specific enzyme–substrate interactions.

References

10

Structure-activity relationships for human estrogenic activity in zearalenone mycotoxins

W. Thomas Shier, Anna C. Shier, Wei Xie et al. · Toxicon · 2001 · 293 citations

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A novel lactonohydrolase responsible for the detoxification of zearalenone: enzyme purification and gene cloning

Naoko Takahashi, Makoto Kimura, Hideaki Kakeya et al. · Biochemical Journal · 2002 · 208 citations · Full text

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Functional Characterization of the Biosynthesis of Radicicol, an Hsp90 Inhibitor Resorcylic Acid Lactone from Chaetomium chiversii

Shuhao Wang, Yuquan Xu, Erin A. Maine et al. · Chemistry & Biology · 2008 · 128 citations

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Metabolism of Zearalenone by Genetically Modified Organisms Expressing the Detoxification Gene from <i>Clonostachys rosea</i>

Naoko Takahashi, Shuichi Ohsato, Takehiko Shibata et al. · Applied and Environmental Microbiology · 2004 · 117 citations · Full text

Toxicities induced in cultured cells exposed to zearalenone: Apoptosis or mutagenesis?

Imen Ayed‐Boussema, Zouhour Ouanes, Hassen Bacha et al. · Journal of Biochemical and Molecular Toxicology · 2007 · 65 citations