Functional Characterization of the Biosynthesis of Radicicol, an Hsp90 Inhibitor Resorcylic Acid Lactone from Chaetomium chiversii

Structural Basis for Inhibition of the Hsp90 Molecular Chaperone by the Antitumor Antibiotics Radicicol and Geldanamycin

S. Mark Roe, Chrisostomos Prodromou, Ronan O’Brien et al. · Journal of Medicinal Chemistry · 1999 · 991 citations · Full text

Protein Assembly, Molecular Biology, Antimicrobial Chemotherapy +20

Conserved Amino Acid Residues Correlating With Ketoreductase Stereospecificity in Modular Polyketide Synthases

Patrick Caffrey · ChemBioChem · 2003 · 363 citations

Biosynthesis, Aldehyde Dehydrogenase, Biochemistry +14

A gene cluster for macrolide antibiotic biosynthesis in <i>Streptomyces venezuelae</i> : Architecture of metabolic diversity

Yongquan Xue, Lishan Zhao, Hung‐wen Liu et al. · Proceedings of the National Academy of Sciences · 1998 · 350 citations · Full text

Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in <i>Streptomyces</i> <i>avermitilis</i>

Haruo Ikeda, Tomoko Nonomiya, Masayo Usami et al. · Proceedings of the National Academy of Sciences · 1999 · 344 citations · Full text

The biosynthetic gene cluster for the microtubule-stabilizing agents epothilones A and B from Sorangium cellulosum So ce90

István Molnár, Thomas Schupp, M. ONO et al. · Chemistry & Biology · 2000 · 296 citations · Full text

Biosynthesis, Engineering, Biotransformation +10