Perinatal lethality with kidney and pancreas defects in mice with a targetted Pkd1 mutation

The polycystic kidney disease 1 (PKD1) gene encodes a novel protein with multiple cell recognition domains

Jim R. Hughes, Christopher J. Ward, Belén Peral et al. · Nature Genetics · 1995 · 916 citations

Medicine, Molecular Biology, Molecular Genetics +8

Polycystic kidney disease: The complete structure of the PKD1 gene and its protein

Cell · 1995 · 619 citations · Full text

Medicine, Genetics, Molecular Genetics +12

The Molecular Basis of Focal Cyst Formation in Human Autosomal Dominant Polycystic Kidney Disease Type I

Feng Qian, Terry Watnick, Luiz F. Onuchic et al. · Cell · 1996 · 615 citations · Full text

Medicine, Genetics, Molecular Genetics +11

A dominant mutation in the Ikaros gene leads to rapid development of leukemia and lymphoma

Susan Winandy, Paul W. Wu, Katia Georgopoulos · Cell · 1995 · 527 citations · Full text

Life Sciences, Genetics, Molecular Genetics +10

Loss of the polycystic kidney disease (PKD1) region of chromosome 16p13 in renal cyst cells supports a loss-of-function model for cyst pathogenesis.

J L Brasier, Elizabeth P. Henske · Journal of Clinical Investigation · 1997 · 260 citations · Full text

Medicine, Genetics, Molecular Genetics +17