A dominant mutation in the Ikaros gene leads to rapid development of leukemia and lymphoma

A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

Stephen Friend, René Bernards, Snezna Rogelj et al. · Nature · 1986 · 3K citations · Full text

Medicine, Genetics, Molecular Genetics +12

RAG-1-deficient mice have no mature B and T lymphocytes

Peter Mombaerts, John Iacomini, Randall S. Johnson et al. · Cell · 1992 · 2.9K citations

Life Sciences, Genetics, Immunology +13

T cell receptor antagonist peptides induce positive selection

Kristin A. Hogquist, Stephen C. Jameson, William R. Heath et al. · Cell · 1994 · 2.9K citations

Life Sciences, Immunology, Molecular Biology +13

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

Yoichi Shinkai · Cell · 1992 · 2.6K citations

Life Sciences, Genetics, Immunology +14

Expression of recessive alleles by chromosomal mechanisms in retinoblastoma

Webster K. Cavenee, Thaddeus P. Dryja, Robert A. Phillips et al. · Nature · 1983 · 1.9K citations

Life Sciences, Genetics, Molecular Genetics +14