Simvastatin Rescues Rats From Fatal Pulmonary Hypertension by Inducing Apoptosis of Neointimal Smooth Muscle Cells

Heterozygous germline mutations in BMPR2, encoding a TGF-β receptor, cause familial primary pulmonary hypertension

Kirk B. Lane, Rajiv D. Machado, Michael W. Pauciulo et al. · Nature Genetics · 2000 · 1.5K citations

Hypertension, Pulmonary Arterial Hypertension, Tgf-β Receptor +11

The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals.

Yasuko Kureishi, Zhengyu Luo, Ichiro Shiojima et al. · Nature Medicine · 2000 · 1.4K citations

Angiogenesis, Molecular Physiology, Cardiovascular Disease +13

Statins as a newly recognized type of immunomodulator

Brenda R. Kwak, Flore Mulhaupt, Samir Myit et al. · Nature Medicine · 2000 · 1.4K citations

Inflammation, Autoimmune Disease, Allergy +6

Familial Primary Pulmonary Hypertension (Gene PPH1) Is Caused by Mutations in the Bone Morphogenetic Protein Receptor–II Gene

Zemin Deng, Jane H. Morse, Susan L. Slager et al. · The American Journal of Human Genetics · 2000 · 1.2K citations · Full text

Hypertension, Gene Pph1, Developmental Biology +11

HMG-CoA reductase inhibition by atorvastatin reduces neointimal inflammation in a rabbit model of atherosclerosis

Carmen Bustos, Miguel Ángel Hernández-Presa, Mónica Ortego et al. · Journal of the American College of Cardiology · 1998 · 421 citations

Inflammation, Metabolic Syndrome, Vascular Disease +13